Buy Retin A Cream

Pharmacological action of Retin A:

Natural metabolite of retinol, violates the expression of gene that causes changes in protein synthesis. Passes through cell membranes and form complexes with specific cytoplasmic receptors, which penetrate into the cell nucleus and bind to DNA. Depending on the tissue is induced (started the process of transcription and increases the number of m-RNA) and inhibited protein synthesis. Tretinoin inhibits the gene transcription factor (AP-I), thereby reducing or eliminating the synthesis of metalloproteinases and leveling the negative effects of sunlight on the skin (including hyperpigmentation). Tretinoin reduces the content of melanin in the epidermis, but information about changing the number and size of melanocytes are absent. Preparation itself does not stop the sun’s rays and is not used as a protective agent from sunburn. Induction of transcription leads to an increase in the number of epithelial cells in a state of mitosis, which contributes to the processes of proliferation in the papillary layer of the skin and the renewal of the epithelium, decreases the adhesion of cells involved in the formation of acne vulgaris, prevents the formation of keratin plugs increases the synthesis of glycosaminoglycan-like substances in the stratum layer of the epithelium. When handling open acne promotes equalization of the skin surface without signs of inflammation. When handling sealed acne promotes their transition into the open pimples or papules, which then heal without scarring after the removal of keratin plugs. Prevents the formation of new acne. There is evidence that tretinoin inhibits the synthesis of keratin, which promotes hair growth (slightly) and has weak anti-tumor effect.

Prescribed Retin A:

Retin A Cream on the oil-water-based gel for topical application and solution for outdoor applications: acne vulgaris (including the formation of comedones, papules, pustules, blackheads drain); follicular keratosis and flat warts. Cream on the water-oil-based: hyperpigmentation, tuberosity and wrinkled surface skin of the face caused by exposure to sunlight (as adjunctive therapy).

Contra Retin A:

Hypersensitivity, pregnancy, lactation, children under the age of 12 years (for all indications), and 18 (for the treatment of adverse effects of sunlight), age over 50 years (for the treatment of adverse effects of sunlight). C care. Seborrheic dermatitis, eczema, sunburn, hepatic failure, pancreatitis, chronic renal failure, chronic intoxication (including alcohol intoxication), diabetes mellitus.

Side effects of Retin A:

Local reactions: allergic reactions (from mild to severe) – tingling, redness, burning, and swelling at the site of application of the drug, photosensitivity, skin hypopigmentation, peeling and dry skin, blisters or crusts, rarely – hyperpigmentation of the skin.

Administration and Dosage Retin A:

Externally applied to the affected places a very thin layer (gel or cream applied to his finger, lotion and solution – with a cotton swab) 1 every evening before bedtime, leave on skin for 6 h, followed by a wash in running water, if necessary, the multiplicity of application increased to 2 times per day. For people with fair and dry skin during exposure of the drug early in treatment is 30 minutes, then it can be gradually increased. The treatment allowed carefully remove completely softened comedones and pustules. Duration of treatment depends on the type of pathology: the treatment of acne vulgaris therapeutic effect occurs within 2-3 weeks, in most cases – in 6-7 weeks, the best clinical outcome is achieved after 3 months of therapy in the treatment of adverse effects from exposure to sunlight – after 4 -24 weeks. For preventive purposes – 1 times a week, after a warm bath. Treatment of flat warts begin with low concentrations of tretinoin in the absence of clinical effect increases as the concentration of the drug and the frequency of its use (in the absence of effects of skin irritation).

Special instructions:

When applied externally to avoid contact with eyes, mouth, mucous membranes (in the case of contact, wash immediately with water.) During the period of treatment is recommended to avoid sun exposure. Patients having a tan, you can begin treatment after the weakening sun. After 1 week of therapy may increase the appearance of acne, which is associated with the action of the drug on the deep-seated acne, which were not visible before treatment. Should not be prescribed together with drugs that cause desquamation of the epithelium, as well as cosmetic and hygiene products, causing dryness and irritation. Sometimes, for the treatment of acne vulgaris recommend the simultaneous appointment of oral isotretinoin and the local form of tretinoin, in this case of adverse effects or reduce the dose of one of the retinoids, or cancel it before the disappearance of adverse events. In the treatment of follicular keratosis symptoms of irritation may be reduced by co-administration of local corticosteroids. Should not be used for the treatment of acne vulgaris cream on the water-oil-based. It should be borne in mind that tretinoin as a single agent is used to treat acne vulgaris I and II, Art. gravity. In more severe cases, to enhance the therapeutic effect of tretinoin is recommended combination with antibiotics (local and systemic), or benzoyl peroxide. Efficacy and safety in the treatment of photochemical dermatosis and skin tumors have not been established. Tretinoin should not be used for deep wrinkles, yellowing of the skin, telangiectasia, “sluggish” skin, melanocytic atypia, elastosis skin.

Interaction Retin A:

Simultaneous application of tretinoin with topical antibiotics (clindamycin, erythromycin), benzoyl peroxide, resorcinol, salicylic acid and astringent, aftershave, with products containing pillingovye matter, sulfur, ethanol, cosmetics, soaps and tools for hair care, causing dry skin, substances that contain lemon or having the abrasive effect can cause increased irritation and dryness of the skin (requires either reducing the dose of tretinoin, or temporary cessation of treatment before the disappearance of adverse effects). Increases the rate and systemic absorption of minoxidil (local form), which contributes to hair growth and increases the risk of skin irritation (concurrent use is not recommended). The simultaneous use with drugs that increase photosensitivity (including fluoroquinolones, phenothiazines, sulfonamides, thiazide diuretics) increases the risk of photosensitization (especially in the first months of treatment), which requires either reducing the dose of tretinoin, or suspending its application to the disappearance of adverse effects. In an application with other retinoids (acitretin, etretinate, isotretinoin, oral tretinoin) enhances the dryness and irritation.